RNase 7 in Cutaneous Defense.
نویسندگان
چکیده
RNase 7 belongs to the RNase A superfamily and exhibits a broad spectrum of antimicrobial activity against various microorganisms. RNase 7 is expressed in human skin, and expression in keratinocytes can be induced by cytokines and microbes. These properties suggest that RNase 7 participates in innate cutaneous defense. In this review, we provide an overview about the role of RNase 7 in cutaneous defense with focus on the molecular mechanism of the antimicrobial activity of RNase 7, the regulation of RNase 7 expression, and the role of RNase 7 in skin diseases.
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ورودعنوان ژورنال:
- International journal of molecular sciences
دوره 17 4 شماره
صفحات -
تاریخ انتشار 2016